Bacterial Cell wall Biosynthesis

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Bacterial Cell wall Biosynthesis

The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves enzyme reactions that take place in the cytoplasm and on the inner side and outer side of the cytoplasmic membrane. This review deals with the cytoplasmic steps of peptidoglycan biosynthesis, which can be divided into four sets of reactions that lead to the syntheses of
(1) UDP-N-acetylglucosamine from fructose 6-phosphate,
(2) UDP-N-acetylmuramic acid from UDP-N-acetylglucosamine,
(3) UDP-N-acetylmuramyl-pentapeptide from UDP-N-acetylmuramic acid and
(4) d-glutamic acid and dipeptide d-alanyl-d-alanine.

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