Inhibitors of Bacterial Cell Wall Synthesis

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Inhibitors of Bacterial Cell Wall Synthesis

A number of drugs inhibit cell wall synthesis. Most important are vancomycin, which targets monomer polymerization; and the β-lactams, e.g., penicillins and cephalosporins, which block polymer cross-linking. β-lactam antibacterial agents also activate autolysins. Autolysins punch holes in bacterial cell wall and disrupt its integrity. Transpeptidase antagonism and autolysis prevent bacterial self-maintenance, i.e., remodeling and repair; and replication.

Vancomycin is bactericidal in susceptible organisms. It is primarily effective against aerobic gram-positive cocci and bacilli.

Penicillin is a group of antibiotics, derived originally from common moulds known as Penicillium moulds; which includes penicillin G, penicillin V, procaine penicillin, and benzathine penicillin.

The cephalosporins are bactericidal in susceptible organisms. Most are primarily active against aerobic gram-positive cocci and bacilli.

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